EIMEC Clinical Study — CREGEN Independent Validation
🇪🇺 EIMEC Barcelona Independent Validation

The Independent
Study Behind
CREGEN.

The European Institute of Medical and Exercise Cognition ran an independent controlled pilot study on CREGEN — with no stake in the outcome. Early results point to better creatine retention and bioavailability than market competitors.

Controlled pilot study 15-day protocol 5g daily dose EU cohort — independent
EIMEC
European Institute of Medical
and Exercise Cognition
Barcelona, Spain · EU Registered
15d
Duration
5g
Daily dose
56%
Lower urinary loss
0
Conflicts of interest
Controlled EU Cohort Independent 3rd Party
56% Lower urinary loss
+26% Higher plasma creatine
+23% Higher serum creatine
p<0.05 Significant retention
0 Adverse events
Why It Matters

EIMEC Had No Stake
in the Outcome.

EIMEC did not create CREGEN. They did not fund CREGEN. They are not affiliated with CREGEN or with KAIST. Their only job was to verify whether the science held up — with their own cohort, their own protocol, their own methodology.

That is what makes the result meaningful. KAIST invented the CGG Amino-Bridge™. EIMEC, an independent EU institution in Barcelona, set out to challenge it. The data matched.

🏛️
EU-Registered Institution
EIMEC is an independent European research body — not a commercial lab, not a marketing partner.
🌍
Separate European Cohort
A small controlled cohort recruited in the EU — a separate population from the original KAIST Korean cohort.
📋
No Shared Methodology
EIMEC designed its own study protocol independently. They were testing a claim, not confirming one they wrote.
Research Chain of Evidence
🇰🇷
KAIST
Korea Advanced Institute of Science & Technology · Daejeon, KR
Discovery
Independent verification
🇪🇺
EIMEC
European Institute of Medical and Exercise Cognition · Barcelona, ES
Validation
Result
56%
Lower urinary loss (p<0.05)
EIMEC Study Results

What the Pilot Study Found.

EIMEC tracked creatine across serum, plasma, and urinary markers. The standout result: significantly lower urinary creatine loss versus a competitor — with consistent directional trends toward higher serum and plasma levels. Preliminary data from a small controlled cohort.

56%
Lower Urinary Loss
Significantly less creatine excreted in spot urine versus a leading competitor (p=0.028) — the study's one statistically significant result. The body retains more instead of flushing it out.
Statistically Significant
+26%
Higher Plasma Creatine
Plasma creatine ran higher than the competitor — a directional trend toward greater systemic availability, not yet statistically significant at this pilot's small sample size.
Directional Trend
+23%
Higher Serum Creatine
Serum creatine trended higher than the competitor, consistent with better retention — a promising signal awaiting confirmation in a larger study.
Directional Trend
0
Adverse Events
CREGEN was well tolerated across all participants, with no adverse effects reported during the study and a favorable short-term safety profile.
Safety

CREGEN vs Competitor 1 — Creatine Markers

Mean values per marker (n=2 per group · 5 g/day · 15 days). Bars are scaled within each marker pair so the comparison is visible across very different units; exact values are labelled on every bar.

Mean concentration (scaled per marker) 127.2 225.3 Clearance p=0.588 · ns 111.1 90.5 Serum p=0.213 · trend ↑ 142.9 219.2 Urine 24h p=0.625 · ns 833.3 1900.0 Urine spot * p=0.028 · significant * 149.8 119.1 Plasma p=0.116 · trend ↑

* p<0.05 (statistically significant). Urine-spot creatine was ~56% lower with CREGEN (833.3 vs 1900.0) — less creatine flushed out, better retention. Serum and plasma trended higher (more in circulation) but did not reach significance at this pilot's small sample. Pilot study — preliminary and exploratory; larger studies are needed to confirm.

Behind the Study

Scientific Team & Facilities

The EIMEC study was conducted by an independent team of researchers at their Barcelona facilities — no affiliation with CREGEN or KAIST.

EIMEC lead researcher reviewing clinical data

Lead Researcher

Clinical Bioavailability Analysis

EIMEC scientist conducting study protocols

Research Scientist

Molecular Transport Protocols

EIMEC Barcelona research facility exterior

Research Facility · Barcelona

EU-regulated clinical research environment

EIMEC laboratory study environment

Study Environment

Controlled pilot cohort study

Study Design

How the Study Was Conducted

EIMEC designed its own independent methodology. No shared protocol with KAIST. No access to the original study design. A clean, independent verification.

👥
Controlled Pilot Cohort
Physically active adult volunteers compared against market competitor products under standardized conditions. A small early-stage sample, designed to validate the methodology for larger trials.
Population
🔒
Controlled Conditions
Participants followed standardized training and lifestyle guidelines, minimizing external variability so the comparison between products was as clean as possible.
Design
📅
15-Day Protocol
Participants took 5g of product daily for 15 days, with baseline and follow-up blood and urine analyses capturing the distribution and elimination profile of creatine.
Duration
🧪
Multiple Biological Markers
Creatine was tracked across serum, plasma, clearance, and urinary excretion (spot and 24-hour) and analyzed with Welch's t-test — appropriate for a small, controlled sample.
Measurement
⚖️
Equivalent Dose Comparison
CREGEN and standard creatine monohydrate were tested at the same dose. Any difference in bioavailability markers reflects the CGG Amino-Bridge delivery mechanism, not dosage differences.
Control
🏛️
No Financial Relationship
EIMEC received no payment from CREGEN or Nuderma Group for conducting this study. The research was conducted as an independent institutional initiative.
Independence
On data transparency: The figures on this page are drawn directly from the EIMEC bioavailability study. Full study summaries — covering methodology, cohort demographics, and the complete dataset — are available on request to verified retail partners, practitioners, and customers. Contact info@cregenusa.com to request access.
Two Institutions. One Result.

KAIST Invented It.
EIMEC Verified It.

Different countries. Different populations. Different methodologies. Same conclusion. That is the standard CREGEN holds its science to.

🇰🇷
Discovery
KAIST
Korea Advanced Institute of Science & Technology
Daejeon, South Korea
  • Developed the CGG Amino-Bridge™ delivery mechanism to improve creatine absorption and bioavailability over standard monohydrate
  • Early research pairing creatine monohydrate with glycine and glutamine to improve absorption and retention
  • Origin of the early/preclinical research behind the CGG Amino-Bridge delivery approach
  • Ranked among Asia's top 5 science and technology universities
🇪🇺
Independent Validation
EIMEC
European Institute of Medical and Exercise Cognition
Barcelona, Spain · EU Registered
  • Conducted an independent controlled pilot study measuring creatine bioavailability in an EU cohort
  • No financial relationship with CREGEN or Nuderma Group — zero conflict of interest
  • Designed its own study protocol independently — did not replicate the KAIST methodology
  • Pointed in the same direction as the KAIST findings — better creatine retention and bioavailability (preliminary)
Good to Know

Questions About the Study

What exactly did EIMEC measure?

EIMEC measured bioavailability — how much of the creatine in CREGEN actually enters and stays in the bloodstream versus being excreted. They tracked creatine across serum, plasma, clearance, and urinary excretion. The standout result was significantly lower urinary creatine loss versus a competitor (p<0.05), with directional trends toward higher serum and plasma creatine. As a pilot study, the results are preliminary.

What is the difference between KAIST and EIMEC?

KAIST — the Korea Advanced Institute of Science and Technology — is where the CGG Amino-Bridge™ technology was discovered and developed. EIMEC, an independent European institute in Barcelona, ran its own study on a completely separate European population to verify those findings from the outside. One created the science; the other checked it with no conflict of interest.

What does the bioavailability result actually show?

The pilot tracked how much creatine is absorbed and retained versus excreted. CREGEN showed significantly lower urinary creatine loss (p<0.05) and higher serum and plasma levels than a competitor — pointing toward greater systemic bioavailability driven by the CGG Amino-Bridge™ delivery system. Because the sample was small, these are preliminary findings that larger studies are designed to confirm.

Can I request the full study data?

Yes. Full study summaries — covering methodology, cohort demographics, and the complete dataset — are available on request to verified retail partners, healthcare practitioners, and serious customers. Email info@cregenusa.com with your details and we will send access within 2 business days.

Why does an independent validation matter if KAIST already published?

A single study — however rigorous — is one data point. Independent replication by a separate institution, with a different cohort and methodology, is the standard by which science earns trust. EIMEC's corroboration of the KAIST findings means the result was not a statistical outlier, not a Korean-population-specific effect, and not influenced by any shared institutional interest. That is what "validated" means in a scientific context.

EIMEC Pilot · KAIST Origin

Independent.
Transparent.

An independent pilot pointing in a promising direction (preliminary). Try CREGEN for 30 days — or get a full refund. No questions asked.