CGG Amino-Bridge™ Technology — CREGEN

Proprietary Delivery Technology

The Science Behind
CGG Amino-Bridge™

Much of standard creatine is lost before your body can use it. CGG Amino-Bridge™ is CREGEN's amino acid delivery approach — pairing creatine with glycine and glutamine to improve absorption, retention and bioavailability for brain and body.

Developed at KAIST
Tested by EIMEC Barcelona (pilot)
Nuderma Group LLC

CGG Amino-Bridge™ Performance Data

~56%
Lower Urinary Creatine Loss vs Competitor (EIMEC pilot)
Retention & Bioavailability
0
Loading Days
1
Sachet / Day
0g
GI Bloating
KAIST Developed EIMEC Pilot GMP Certified Made in USA
~56% Lower Urinary Loss (pilot)
3 Amino Acids — Cr·Gly·Gln
0 Loading Phase
1 Sachet Per Day
The Limitation

Most Standard Creatine Is Lost Before You Use It

Creatine monohydrate has been studied for decades, and its role in cellular energy and ATP resynthesis is well established. The challenge isn't whether creatine works — it's how much of each dose your body actually absorbs and holds onto.

A meaningful share of orally ingested creatine is poorly absorbed or excreted before tissues can use it — much of it lost in the urine. That means a lot of every standard dose is wasted, which is why high doses and loading phases became common workarounds.

The goal of a better delivery system is simple: improve absorption and retention so more of each dose reaches and stays in the tissue that needs it — supporting energy in both body and brain.

60–70% Bioavailability
Up to 40% of standard creatine is lost before reaching target tissue — excreted before absorption is complete.
High Urinary Loss
A significant portion of standard creatine is excreted in the urine rather than retained — so much of each dose never gets used.
5–7 Day Loading Phase Required
Saturation loading at 20g/day is needed to approach tissue saturation — causing GI distress and water retention.
GI Bloating & Water Retention
High-dose creatine monohydrate draws water into muscle cells, causing visible bloating and gastrointestinal discomfort.

Where Standard Creatine Is Lost

💊
Oral Dose
Creatine ingested
100%
🚽
Absorption & Retention
A large share is excreted in urine
Lost
Reaches Your Tissue
Only the retained fraction is used
Reduced
Result: Standard creatine monohydrate works, but a meaningful portion of each dose is lost to urinary excretion before tissues can use it — lowering effective bioavailability.
The CGG Solution

How CGG Amino-Bridge™ Works

A three-stage delivery approach designed to improve absorption and retention — so more of each creatine dose is held onto and made available to your tissues.

1
⚗️
Formulation

CGG Complex Assembly

Creatine monohydrate is paired with Glycine and Glutamine into the CGG Amino-Bridge™ complex. The pairing is designed to support the body's amino-acid transport pathways and improve how much creatine is absorbed and retained.

Creatine + Glycine + Glutamine
Co-formulated amino-acid pairing
Aimed at absorption & retention
2
🔬
Absorption

Improved Uptake & Retention

Pairing creatine with glycine and glutamine is intended to support amino-acid transport pathways and reduce how much creatine is lost before it can be used — keeping more of each dose available to the body.

Co-delivered with supporting amino acids
Designed to lower urinary loss
Lower urinary loss observed in EIMEC pilot
3
Cellular Uptake

Dual-Tissue Cellular Uptake

With more creatine absorbed and retained, more is available for cellular energy and ATP resynthesis — the well-documented role creatine plays in both muscle and the brain — from a single daily dose.

More creatine retained and available
Neuronal & muscle saturation simultaneously
Greater measured bioavailability (preliminary)
The CGG Complex

Three Amino Acids. One Bridge.

CGG stands for Creatine-Glycine-Glutamine. Each component plays a critical, non-redundant role in the delivery mechanism. This is not a blend — it is a bonded complex where each molecule is structurally essential.

Cr
Creatine
ATP resynthesis — fuel for muscle & brain energy
Primary
Gly
Glycine
Structural backbone — supports amino-acid transport & absorption
Carrier
Gln
Glutamine
Retention support — the amino-bridge mechanism
Bridge

Delivery Pathway vs Standard

Oral Ingestion
CGG Complex — single sachet
GI Absorption
Improved absorption — gentle on the gut
Retention
Less lost to urine — more held in tissue
Dual Tissue Uptake
Brain + muscle — simultaneous delivery
Cellular ATP Resynthesis
More creatine available for energy
Why CGG Is Different

Four Reasons CGG Is Different

Where measured, these point back to an independent EIMEC pilot study — preliminary findings, honestly framed, not marketing claims.

🧠
~56%
Lower Urinary Loss vs Competitor
Better Retention
In the EIMEC pilot, CREGEN showed about 56% lower urinary creatine loss than a competitor (p=0.028) — meaning more of each dose was retained rather than excreted. Preliminary; larger studies needed.
EIMEC Pilot (preliminary)
💊
Directional Trend (pilot)
Greater Bioavailability
The same pilot showed directional, not-yet-significant trends toward higher serum (~+23%) and plasma (~+26%) creatine for CREGEN — consistent with better absorption. Exploratory; to be confirmed in larger studies.
Independent Pilot Study
📅
0
Loading Days Required
No Loading Phase
Standard creatine often uses a 5–7 day loading phase at 20g/day. CGG Amino-Bridge is designed for one sachet, once daily — no loading phase required.
Immediate Protocol
Zero
Bloating or Retention
No GI Side Effects
With better absorption and a low daily dose, there's far less unabsorbed creatine to draw water into the gut — helping avoid the bloating and cramping linked to high-dose loading.
Gentle Daily Protocol
Head-to-Head

CREGEN CGG vs Standard Creatine

A direct comparison across every metric that matters — from molecular delivery to day-to-day user experience.

Feature Standard Creatine Monohydrate CREGEN CGG Amino-Bridge™
Bioavailability Limited by urinary loss Greater (preliminary)
Urinary Creatine Loss Higher — much excreted ~56% lower vs competitor (pilot, p<0.05)
Retention & Absorption Lower — needs high doses Improved by amino-acid pairing
Loading Phase Required 5–7 days at 20g/day None — immediate saturation
Daily Dose 3–5g (maintenance) · 20g (loading) 1 sachet per day
GI Bloating Common — especially loading None — zero GI complaints
Water Retention Visible in loading phase No subcutaneous retention
Muscle + Brain Delivery Muscle only Dual-tissue simultaneous
Timing Windows Pre/post workout recommended Anytime — no timing required
Independent Testing General literature only EIMEC Barcelona — controlled pilot (preliminary)
Research Origin Generic synthesis KAIST — South Korea
🇰🇷
KAIST
Korea Advanced Institute of Science & Technology — early research origin
🇪🇸
EIMEC Barcelona
European Institute of Medical & Exercise Cognition — independent pilot
🇺🇸
Nuderma Group LLC
Miami, FL — GMP Certified Manufacturing
📄
Full Study Report
EIMEC independent pilot study — read the details →
CGG Amino-Bridge™ Protocol

Get More From
Every Creatine Dose

One sachet. No loading phase. No bloating. The CGG Amino-Bridge™ approach to creatine for brain and body — built on early research from KAIST and tested in an independent EIMEC pilot.

30-Day Money-Back
Free Shipping $149+
GMP Certified USA
KAIST research + EIMEC pilot